PDF PRISMA System - CRRT Online . PRISMA® System An integrated system for continuous fluid management, renal replacement therapies and therapeutic plasma exchange Operator's Manual For use with software versions R03.10 PDF The PRISMAFLEX System - econnect.baxter.com . The PRISMAFLEX Control Unit is intended for: • Continuous Renal Replacement Therapy (CRRT) for patients weighing 20 kilograms or more with acute renal failure and/or fluid overload. • Therapeutic Plasma Exchange (TPE) therapy for patients weighing 20 kilograms or more with diseases where fluid removal of plasma components is indicated.